Isoapoptolidin CAS 476647-30-0

Subscribe to our newsletter!

Welcome | LOG OUT

I9039-95 Isoapoptolidin CAS: 476647-30-0

Specifications

References

CAS Number

476647-30-0

Grade

Highly Purified

Molecular Formula

C58H96O21

Molecular Weight

1129.4

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Isopoptolidin, originally isolated from a Nocardiopsis sp., is a ring expanded isomer of apoptolidin. In water an equilibrium mixture of apoptolidin/isoapoptolidin (~1.5:1) is formed within hours. In a rapid F0F1-ATPase assay isoapoptolidin exhibited a IC50 of 17 uM compared to 0.7 uM for apoptolidin.

Purity: >90% by HPLC

Solubility: Soluble in ethanol, methanol, DMF or DMSO.

Related to: Apoptolidin

Source

Amycolatopsis sp.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Isoapoptolidin: structure and activity of the ring-expanded isomer of apoptolidin. Wender P.A. et al. Org. |Lett. 2002, 4, 3819. |2. Toward a stable apoptolidin derivative: identification of isoapoptolidin and selective deglycosylation of |apoptolidin. Pennington J. D. et al. Org. Lett. 2002, 4, 3823. |3. Apoptolidin analogs and derivatives for inducing apoptosis in transformed cells. Wender P.A. et al. |US Patent Application, 20040180841.