O-3-Amino-3-deoxy-α-D-glucopyranosyl-(16)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(14)]-2-deoxy-D-streptamine Sulfate; Cantrex; Cristalomicina; Enterokanacin; Kamycin; Kanabristol; Kanamytrex; Kanaqua; Kanasig; Kanatrol; Kanescin; Otokalixin; Resistomycin; Amikacin EP Impurity D Sulfate
Kanamycin sulfate is an antibiotic that belongs to the group of drugs called aminoglycosides. It binds to ribosomal components and inhibits protein synthesis. Kanamycin sulfate appears to prevent bacteria from making their cell walls, thus the cells die. It is used to treat many sensitive gram-negative, some gram-positive bacteria and and mycoplasmas in cell culture. Kanamycin is inactivated by an aminoglycoside phospho transferase (MW 25,000) in the periplasmic space. Suitable for use as a selectable marker for cosmid vectors used in transfection of mammalian cells.
Synonyms
O-3-Amino-3-deoxy-α-D-glucopyranosyl-(16)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(14)]-2-deoxy-D-streptamine Sulfate; Cantrex; Cristalomicina; Enterokanacin; Kamycin; Kanabristol; Kanamytrex; Kanaqua; Kanasig; Kanatrol; Kanescin; Otokalixin; Resistomycin; Amikacin EP Impurity D Sulfate
Molecular Formula
C18H36N4O11•H2SO4
Activity on Dry Basis
≥750ug/mg
Appearance
White to light tan crystalline powder
Identity
To pass USP Test
Specific Rotation
+112° to +123°
Residue on Ignition
≤0.5%
Working Concentration
Cell/Tissue Culture: ~30ug/ml Stringent Plasmids: 10ug/ml Relaxed Plasmids: 50ug/ml
Storage and Stability
May be stored at 4°C. Stable for 12 months after receipt.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
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