Coenzyme in the oxidative decarboxylation reactions of glucose metabolism and the citric acid cycle. Although it is an essential growth factor for various micro-organisms. a-Lipoic acid, is a naturally occuring coenzyme containing a disulfide that has been used to treat polyneuropathies and hepatic disorders. a-Lipoic acid is a potent inhibitor of NFKB activation and HIV-1 tat driven gene expression.
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