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P3109-30 Parathyroid Hormone, Recombinant, Human (PTH) (1-84) CAS:

Specifications
References
Swiss Prot
P01270
Grade
Purified
Accession Number
NP_000306
Molecular Weight
9.55
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C

Human parathyroid hormone (hPTH) is an 84 amino acid residue peptide and one of the main regulators in maintenance of calcium homeostasis. It acts primarily on kidney and bone cells stimulating calcium back resorption or calcium mobilization, respectively. The whole mechanism is still under discussion, but low-dose hPTH triggers cyclic AMP-dependent protein kinase in some populations of bone cells bearing PTH receptors, which stimulates the proliferation of osteoblasts.

Recombinant protein corresponding to aa1-84 from human parathyroid hormone, overexpressed in E. coli.
Molecular Weight
~9.55kD (85aa) confirmed by MALDI-TOF
AA Sequence
MSVSEIQLMH NLGKHLNSME RVEWLRKKLQ DVHNFVALGA PLAPRDAGSQ RPRKKEDNVL VESHEKSLGE ADKADVNVLT KAKSQ
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Concentration
~1mg/ml (determined by absorbance at 280nm)
Form
Supplied as a liquid in PBS, pH 7.4, 2mM EDTA.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Hodsman, A.B., et al., (2003) J. Clin. Endocrinol. Metab. 88(11): 5212-5220 (2003). |2. Wingender, E., et al., J. Biol. Chem. 264(8): 4367-4373 (1989).
USBio References
No references available
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