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P9182-35B-ML650 PC Cell-derived Growth Factor (PCDGF) (MaxLight 650) CAS:

Specifications
References
Brand
MaxLight™
Grade
Affinity Purified
EU Commodity Code
30021010
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze
Notes
Preservative Free
BSA Free

MaxLight™ 650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000.

PCDGF, also known as PC cell-derived growth factor, GP88, acrogranin, granulin precursor, epithelin precursor, or progranulin, is a glycoprotein and growth factor involved in tumorigenesis, the regulation of mitosis, non-neoplastic proliferative disorders, early embryonic development, cell division, cell invasion, cell survival, and hypothalamic differentiation. Because PCDGF regulates multiple steps during carcinoma progression, it may represent a future therapeutic target. PCDGF mediates resistance to the cancer drug tamoxifen, and promotes tumor growth of human breast cells. Breast cancer samples that are estrogen receptor-positive and also overexpress PCDGF may therefore represent adverse consequences for patients if they are treated with tamoxifen. PCDGF may promote metastasis and angiogenesis in human breast cancer cells, in addition to stimulating their proliferation and survival. PCDGF staining is observed in breast carcinoma, whereas it is almost always negative in benign breast epithelium. PCDGF expression is more common in invasive ductal carcinoma than in invasive lobular carcinoma. PCDGF expression in human breast carcinoma correlates with clinicopathological variables such as tumor grade, proliferation index, and p53 expression, suggesting an important role of PCDGF in breast cancer pathogenesis. PCDGF is also expressed in human multiple myeloma (MM) cell lines, human prostatic intraepithelial neoplasma (PIN) and invasive prostatic adenocarcinoma.
Applications
Suitable for use in Immunoprecipitation and Western Blot. Other applications not tested.
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Positive Control
Human MDA-MB-231 breast adenocarcinoma, PC-3 prostate adenocarcinoma (bone metastatic site), HeLa cervical carcinoma, and HT1080 fibrosarcoma lysates.
Storage and Stability
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
References
1. He, Z., et al., Cancer Res. 62(19): 5590-5596 (2002). 2. Tangkeangsirisin, W., et al., Cancer Res. 64(5): 1737-1743 (2004). 3. Tangkeangsirisin, W. and Serrero, G., Carcinogenesis 25(9): 1587-1592 (2004). 4. Serrero, G. and Ioffe, O.B., Human Pathol. 34(11): 1148-1154 (2003). 5. Wang, W., et al., Clin. Cancer Res. 9(6): 2221-2228 (2003). 6. Pan, C.X., et al., Clin. Cancer Res. 10(4): 1333-1337 (2004).
USBio References
No references available
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