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S9500-24A Synuclein, alpha E46K, Recombinant, Human CAS:

Specifications
References
Grade
Highly Purified
Molecular Weight
14459
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C

Alpha Synuclein E46K is a mutant form of alpha synuclein which is changed at position 46 from glutamate (E) to lysine (K). Recent studies have shown that this mutant (E46K) of alpha synuclein causes Parkinson and Lewy Body dementia (DLB). Alpha Synuclein E46K was overexpressed in E. coli.

Molecular Weight
14,459 (Real molecular weight on SDS-PAGE will be shift up)
Sequence
MDVFMKGLSK/ AKEGVVAAAE/ KTKQGVAEAA/ GKTKEGVLYV/ GSKTKKGVVH/ GVATVAEKTK/ EQVTNVGGAV/ VTGVTAVAQK/ TVEGAGSIAA/ ATGFVKKDQL/ GKNEEGAPQE/ GILEDMPVDP/ DNEAYEMPSE/ EGYQDYEPEA
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Purity
≥ 95% by SDS PAGE; Purified to apparent homogeneity by using conventional column chromatography techniques.
Concentration
~1mg/ml (BCA assay)
Form
Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 0.1M sodium chloride.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Zarranz, J.J., et al., Ann. Neurol. 55: 164-173 (2004).
USBio References
No references available
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