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T8416-72 5-Trifluorothymidine CAS: 70-00-8

Specifications
CAS Number
70-00-8
Grade
Highly Purified
MDL Number
MFCD00006534
Molecular Formula
C₁₀H₁₁F₃N₂O₅
Molecular Weight
296.2
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
Trifluridine; Trifluorothymine Deoxyriboside; α,α,α-Trifluorothymidine; 2’-Deoxy-5-(trifluoromethyl)uridine; 5-(Trifluoromethyl)-2’-deoxyuridine; Viroptic

Trifluorothymidine is an inhibitor of TS (thymidylate synthase). It is also a substrate used to study the specificity and kinetics of thymidine kinases. Acts as an anti-herpesvirus drug by blocking viral DNA replication. Decreases CRISPR-mediated HDR (homology-directed repair) efficiency.

Synonyms
Trifluridine; Trifluorothymine Deoxyriboside; α,α,α-Trifluorothymidine; 2’-Deoxy-5-(trifluoromethyl)uridine; 5-(Trifluoromethyl)-2’-deoxyuridine; Viroptic
CAS No
70-00-8
Molecular Formula
C₁₀H₁₁F₃N₂O₅
Molecular Weight
296.20
Appearance
White crystalline powder
Purity
≥99.5% (HPLC)
Infrared Spectrum
Conforms to structure
Loss on Drying
≤1%
5-(Trifluoromethyl)uracil
≤1%
UV Max
260nm
Optical Rotation
[a]D20 = + 49 ± 2º (C=0.3% in H2O)
Melting Point
186-189°C
Solubility
Methanol (Slightly), DMSO (>25 mg/ml), H₂O (>10mg/ml)
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
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