USBio Logo

045205 RBP4 Dual BioAssay™ ELISA Kit (Mouse/Rat) (Retinol Binding Protein 4)

Specifications
References
Brand
BioAssay™
Kit Type
Sandwich ELISA
Tests
96
Sensitivity
60pg/ml
Detection Method
Colorimetric
Detection Range
0.188-12ng/ml
Sample Matrix
Serum, Cell Culture Supernatant and Urine
EU Commodity Code
38220000
UN DOT Shipping
UN2796 PGII
Shipping Temp
Blue Ice
Storage Temp
4°C
Retinol Binding Protein 4

Retinol binding protein 4 (RBP4; RBP) is a 21kD secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function and recent studies have shown an association between serum RBP4 levels and urinary albumin excretion. The urinary RBP4 concentration may be a valuable marker for both, insulin resistance and microalbuminuria in insulin-resistant subjects.

Specificity
Recognizes mouse and rat RBP4. Does not cross-react with human RBP4, mouse adiponectin, mouse resistin, mouse Nampt, rat adiponectin, rat resistin or rat Nampt.
Storage and Stability
Short-term Storage: +4°C Long-term Storage: +4°C
References
Product Reference: |●Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes: Y.M. Cho, et al.; Diabetes Care 29, 2457 (2006)|●High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans: N. Stefan, et al.; Diabetes Care 30, 1173 (2007)|●Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice: R. Sasaki, et al.; Biochem. Pharmacol. 74, 1619 (2007)|●Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice: N. Mody, et al.; Am. J. Physiol. Endocrinol. Metab. 294, E785 (2008)|●Identification and characterization of a non-retinoid ligand for retinolbinding protein 4 which lowers serum retinol-binding protein 4 levels in vivo: A. Motani, et al.; J. Biol. Chem. 284, 7673 (2009)|●Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease: K.S. Collison, et al.; J. Lipid Res. 50, 1521 (2009)|●Diabetes of the Liver: The Link Between nonalcoholic fatty liver disease and HFCS-55: K.S. Collison, et al.; Obesity 17, 2003 (2009)|●Early postnatal oestradiol exposure causes insulin resistance and signs of inflammation in circulation and skeletal muscle: C. Alexanderson, et al.; J. Endocrinol. 201, 49 (2009)|●Dietary trans-fat combined with monosodium glutamate induces dyslipidemia and impairs spatial memory: K.S. Collison, et al.; Physiol. Behav. 99, 334 (2010)|●Effect of dietary monosodium glutamate on HFCS-induced hepatic steatosis: expression profiles in the liver and visceral fat: K.S. Collison, et al.; Obesity (Silver Spring) 18, 1122 (2010)|●Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice: M. Takikawa, et al.; J. Nutr. 140, 527 (2010)|●Increased lipid accumulation in liver and white adipose tissue in aging in the SAMP10 mouse: T. Honma, et al.; J. Nutr. Sci. Vitaminol. (Tokyo) 57, 123 (2011)|●Elevated retinol binding protein 4 contributes to insulin resistance in spontaneously hypertensive rats: H.Y. Ou, et al.; Horm. Metab. Res. 43, 312 (2011)|●Suppression of retinol-binding protein 4 with RNA oligonucleotide prevents high-fat diet-induced metabolic syndrome and non-alcoholic fatty liver disease in mice: Y. Tan, et al.; Biochim. Biophys. Acta 1811, 1045 (2011)|●Peroxisome Proliferator-Activated Receptors-alpha and -gamma, and cAMP-Mediated Pathways, Control Retinol-Binding Protein-4 Gene Expression in Brown Adipose Tissue: M. Rosell, et al.; Endocrinol. (Epub ahead of print) 2012|●
USBio References
No references available
Pricing
Order
Proceed to Checkout
Cart Summary
ProductSizeListYour PriceQtyExt Price
Subtotal:Subtotal:
Subtotal:Subtotal:
Total Coupon Savings:Total Coupon Savings:()
Your cart is currently empty.
- Coupon Code
Recently Viewed
  • Contact Us

    Visit our technical library or contact our support staff to answer your questions.

    Telephone:
    1-800-520-3011

    Library | Contact

    Distributors

    For customers outside of the United States, please use one of our many distributors.

    View Distributors

    Payment Methods

    We accept the following payment methods as well as pay-by-invoice.

    MasterCard Visa PayPal
    © 2023-2024 United States Biological - All Rights Reserved