Adrenomedullin N-20, pro, Human

Purity

~95% (HPLC)

EU Commodity Code

30021019

Shipping Temp

Blue Ice

Storage Temp

4°C

Calcitonin, calcitonin gene-related peptide (CGRP), adrenomedullin (ADM), and amylin belong to a unique group of peptide hormones important for homeostasis in diverse tissues. Calcitonin is essential for calcium balance whereas CGRP and ADM are important for neurotransmission, and cardiovascular and respiratory regulation.

Molecular Weight

~2460.87

Sequence

Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2

Storage and Stability

Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Purity

~95% (HPLC)

Form

Supplied as a white powder.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Sackett et al. Intracellular proadrenomedullin-derived peptides decorate the microtubules and contribute to cytoskeleton function. Endocrinology. 2008 Jun;149(6):2888-98. 2. Pio et al. Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners .J Biol Chem. 2001 Apr 13;276(15):12292-300. 3. Howard et al. Identification of receptors for neuromedin U and its role in feeding.Nature. 2000 Jul 6;406(6791):70-4.

USBio References

No references available

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301834 Adrenomedullin N-20, pro, Human (PAMP-20, Prodepin)

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