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301844 Adrenomedullin, aa1-50, Rat

Specifications
References
Purity
~95% (HPLC)
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
4°C

Calcitonin, calcitonin gene-related peptide (CGRP), adrenomedullin (ADM), and amylin belong to a unique group of peptide hormones important for homeostasis in diverse tissues. Calcitonin is essential for calcium balance whereas CGRP and ADM are important for neurotransmission, and cardiovascular and respiratory regulation.

Source
aa1-50, Rat
Molecular Weight
~5729.49
Sequence
Tyr-Arg-Gln-Ser-Met-Asn-Gln-Gly-Ser-Arg-Ser-Thr-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Met-Gln-Lys- Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Gly-Met-Ala-Pro-Arg-Asn-Lys-Ile-Ser-Pro- Gln-Gly-Tyr-NH2, Disulfide bridge: between Cys14-Cys19
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
~95% (HPLC)
Form
Supplied as a white powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1.Zeng et al. Upregulated expression of intermedin and its receptor in the myocardium and aorta in spontaneously hypertensive rats.Peptides. 2009 Feb;30(2):391-9. 2.Balat et al. Malon dialdehyde, nitrite and adrenomedullin levels in patients with premenstrual syndrome Arch Gynecol Obstet. 2007 May;275(5):361-5. 3.Pan et al. The myocardial response to adrenomedullin involves increased cAMP generation as well as augmented Akt phosphorylationPeptides. 2007 Apr;28(4):900-9. 4.Yılmaz et al. Increased Levels of Nitric Oxide, Cortisol and Adrenomedullin in Patients with Chronic Schizophrenia|Med Princ Pract. 2007;16(2):137-41.5. Balat et al. Adrenomedullin and total nitrite levels in children with familial Mediterranean fever. J Paediatr Child Health. 2006 May;42(5):240-3.6. Ren et al. Intermedin 1-53 in central nervous system elevates arterial blood pressure in rats. Peptides. 2006 Jan;27(1):74-9. 7.Pan et al. Cardiovascular effects of newly discovered peptide intermedin/adrenomedullin 2. Peptides. 2005 Sep;26(9):1640-6. 8. Taylor et al. Intermedin/adrenomedullin-2 acts within central nervous system to elevate blood pressure and inhibit food and water intake. Am J Physiol Regul Integr Comp Physiol. 2005 Apr;288(4):R919-27. 9. Jiang et al. Effects of adrenomedullin on aldosterone-induced cell proliferation in rat cardiac fibroblasts. Biochim Biophys Acta. 2004 Nov 5;1690(3):265-75. 10.Jiang et al. Effects of adrenomedullin on cell proliferation in rat adventitia induced by aldosterone. J Hypertens. 2004 Oct;22(10):1953-61. 11.Luodonpää et al. Adrenomedullin modulates hemodynamic and cardiac effects of angiotensin II in conscious rats.Am J Physiol Regul Integr Comp Physiol. 2004 Jun;286(6):R1085-92.12. Huang et al. Effects of adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide on calcification in cultured rat vascular smooth muscle cells. J Cardiovasc Pharmacol. 2003 Jul;42(1):89-97. 13.Follwell et al. Adrenomedullin influences magnocellular and parvocellular neurons of paraventricular nucleus via separate mechanisms.Am J Physiol Regul Integr Comp Physiol. 2002 Dec;283(6):R1293-302.14. Ladoux et al. Coordinated Up-regulation by Hypoxia of Adrenomedullin and One of Its Putative Receptors (RDC-1) in Cells of the Rat Blood-Brain Barrier*J Biol Chem. 2000 Dec 22;275(51):39914-9.15. Samson et al. Adrenomedullin Inhibits Salt Appetite. Endocrinology. 1997 Feb;138(2):613-6.
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