USBio Logo

301850 Adrenomedullin, aa22-52, Human

Specifications
References
Purity
~95% (HPLC)
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
4°C

Calcitonin, calcitonin gene-related peptide (CGRP), adrenomedullin (ADM), and amylin belong to a unique group of peptide hormones important for homeostasis in diverse tissues. Calcitonin is essential for calcium balance whereas CGRP and ADM are important for neurotransmission, and cardiovascular and respiratory regulation.

Source
aa22-52, Human
Molecular Weight
~3576.03
Sequence
Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-AlaPro-Arg-Ser- Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
~95% (HPLC)
Form
Supplied as a white powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Deng, Boya et al., Adrenomedullin expression in epithelial ovarian cancers and promotes HO8910 cell migration associated with upregulating integrin a5b1 and phosphorylating FAK and paxillin. Journal of Experimental & Clinical Cancer Research, March 9, 2012. 2. Zeng et al. Upregulated expression of intermedin and its receptor in the myocardium and aorta in spontaneously hypertensive rats.|Peptides. 2009 Feb;30(2):391-9.3. Allaker et al. Interaction ofadrenomedullin and calcitonin gene-related peptide with the periodontal pathogen Porphyromonas gingivalis FEMS Immunol Med Microbiol. 2007 Feb;49(1):91-7. 4.Pan et al. The myocardial response to adrenomedullin involves increased cAMP generation as well as augmented Akt phosphorylation Peptides. 2007 Apr;28(4):900-9.5. Allaker et al. Mechanisms of adrenomedullin antimicrobial action. Peptides. 2006 Apr;27(4):661-6.6. Zudaire et al. Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis. Am J Pathol. 2006 Jan;168(1):280-91. 7.Ren et al. Intermedin 1-53 in central nervous system elevates arterial blood pressure in rats. Peptides. 2006 Jan;27(1):74-9. 8.Linscheid et al. Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue.Endocrinology. 2005 Jun;146(6):2699-708. 9.Jiang et al. Effects of adrenomedullin on cell proliferation in rat adventitia induced by aldosteroneJ Hypertens. 2004 Oct;22(10):1953-61. 10. Juaneda et al. Adrenomedullin receptor binding sites in rat brain and peripheral tissues.Eur J Pharmacol. 2003 Aug 8;474(2-3):165-74. 11. Ornan et al. Saturation of adrenomedullin receptors plays an important role in reducing pulmonary clearance of adrenomedullin during the late stage of sepsis. Biochim Biophys Acta. 2002 Apr 24;1586(3):299-306.
USBio References
No references available
Pricing
Order
Proceed to Checkout
Cart Summary
ProductSizeListYour PriceQtyExt Price
Subtotal:Subtotal:
Subtotal:Subtotal:
Total Coupon Savings:Total Coupon Savings:()
Your cart is currently empty.
- Coupon Code
Recently Viewed
  • Contact Us

    Visit our technical library or contact our support staff to answer your questions.

    Telephone:
    1-800-520-3011

    Library | Contact

    Distributors

    For customers outside of the United States, please use one of our many distributors.

    View Distributors

    Payment Methods

    We accept the following payment methods as well as pay-by-invoice.

    MasterCard Visa PayPal
    © 2023-2024 United States Biological - All Rights Reserved