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301863 Agouti-Related Protein amide, aa83-132, Human (AGRP)

Specifications
Purity
~95% (HPLC)
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
4°C

Agouti-Related Protein (AGRP), first identified by Ollman and co-workers is a potent antagonist of MC3-R and MC4-R and is an integral component in the metabolic processes that regulate feeding behavior and body weight. Present in the hypothalamus, AGRP levels are elevated in obese males (Katsuki et al, 2001). has not only identified and synthesized several AGRP fragments that are as potent inhibitors of MC3-R and MC4-R as the parent molecule, but also the intact protein, AGRP Form C (Jimenez et al, 1999). Powerful immunological tools have been developed from these compounds that enable researchers to probe the metabolic processes that lead to obesity.

Source
aa83-132, Human
Molecular Weight
~5676.66
Sequence
Ser-Ser-Arg-Arg-Cys-Val-Arg-Leu-His-Glu-Ser-Cys-Leu-Gly-Gln-Gln-Val-Pro-Cys-Cys-Asp-Pro-Cys- Ala-Thr-Cys-Tyr-Cys-Arg-Phe-Phe-Asn-Ala-Phe-Cys-Tyr-Cys-Arg-Lys-Leu-Gly-Thr-Ala-Met-Asn-Pro- Cys-Ser-Arg-Thr-NH2
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
~95% (HPLC)
Form
Supplied as a white powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
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