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302605 Noto (Homeobox Protein Notochord, Noto, Not)

Specifications
References
Specificity
Recognizes mouse Noto. Species Crossreactivity: mouse
Source Antibody
mouse
Purity
Purified by Protein A affinity chromatography.
Gene ID
384452
Gene #
Noto
EU Commodity Code
30021010
Shipping Temp
Blue Ice
Storage Temp
-20°C

Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate.

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1:4000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
References
Ben Abdelkhalek H.,et al.Genes Dev. 18:1725-1736(2004).|Carninci P.,et al.Science 309:1559-1563(2005).|Yamanaka Y.,et al.Dev. Cell 13:884-896(2007).|Beckers A.,et al.Proc. Natl. Acad. Sci. U.S.A. 104:15765-15770(2007).|
USBio References
No references available
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