RO 28-2653

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4°C

5-[1,1'-Biphenyl]-4-yl-5-[4-(4-nitrophenyl)-1-piperazinyl]-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Biphenyl-4-yl-5-[4-(-nitro-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione

RO 28-2653 exhibits anti-invasive, antitumoral, and antiangiogenic efficacy and is also classified as an orally active and selective matrix metalloproteinases inhibitor with high selectivity for MMP2, MMP9 and membrane type 1-MMP.

Synonyms

5-[1,1'-Biphenyl]-4-yl-5-[4-(4-nitrophenyl)-1-piperazinyl]-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Biphenyl-4-yl-5-[4-(-nitro-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione

CAS No

261956-22-3

Molecular Formula

C₂₆H₂₃N₅O₅

Molecular Weight

485.49

Purity (HPLC)

≥98%

Appearance

Yellow powder

Solubility

DMSO

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at 4°C. Stable for 6 months after receipt

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards

All products should be handled by qualified personnel only, trained in laboratory procedures.

References

1. Maquoi, E. et al.: Clin. Cancer Res., 10, 4038 (2004). 2. Raffetto JD, Khalil RA. Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. Biochem Pharmacol. 2008 Jan 15;75(2):346-59. Epub 2007 Jul 7. Review. PubMed PMID: 17678629; PubMed Central PMCID: PMC2254136

USBio References

No references available

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464780 RO 28-2653

EU Commodity Code

Shipping Temp

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5-[1,1'-Biphenyl]-4-yl-5-[4-(4-nitrophenyl)-1-piperazinyl]-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Biphenyl-4-yl-5-[4-(-nitro-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione

References

USBio References

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