APRIL, Soluble, Recombinant, Human

Grade

Highly Purified

Purity

>95% (SDS-PAGE)

Form

Supplied as a lyophilized powder in PBS pH 7.2.

Specificity

Binds to human and mouse BCMA and TACI. Binds to proteoglycans.

EU Commodity Code

30021019

Shipping Temp

Blue Ice

Storage Temp

-20°C

ACRP30headless:APRIL, ACRP30headless:CD256, ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand:

APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. APRIL is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the NH2 terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.

Biological Activity

Stimulates B cell proliferation.

Sequence

The extracellular domain of human APRIL (aa 88-233) is fused at the N-terminus to human ACRP30headless (aa 16-108) and a FLAG®-tag.

Storage and Stability

Short-term Storage: +4°C Long-term Storage: -20°C Stable for at least 6 months after receipt when stored at -20°C.

Source

Recombinant, HEK293 cells

Purity

>95% (SDS-PAGE)

Concentration

~0.1mg/ml

Form

Supplied as a lyophilized powder in PBS pH 7.2.

Specificity

Binds to human and mouse BCMA and TACI. Binds to proteoglycans.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

Product Reference: |●DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL: M.B. Litinskiy, et al.; Nat. Immunol. 3, 822 (2002)|●APRIL modulates B and T cell immunity: J.V. Stein, et al.; J. Clin. Invest. 109, 1587 (2002)|●Potential role of APRIL as autocrine growth factor for megakaryocytopoiesis: D. Bonci, et al.; Blood 104, 3169 (2004)|●Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL: B. He, et al.; J. Immunol. 172, 3268 (2004)|●BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway: A. Craxton, et al.; J. Exp. Med. 202, 1363 (2005)|●APRIL and BAFF promote increased viability of replicating human B2 cells via mechanism involving cyclooxygenase 2: P.K. Mongini, et al.; J. Immunol. 176, 6736 (2006)|●TACI regulates IgA production by APRIL in collaboration with HSPG: D. Sakurai, et al.; Blood 109, 2961 (2007)|●BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway: T. Endo, et al.; Blood 109, 703 (2007)|●

USBio References

No references available

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- Coupon Code

044567 APRIL, Soluble, Recombinant, Human (ACRP30headless:APRIL, ACRP30headless:CD256, ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand:)

Grade

Purity

Form

Specificity

EU Commodity Code

Shipping Temp

Storage Temp

ACRP30headless:APRIL, ACRP30headless:CD256, ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand:

References

USBio References

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