ZIKV is closely related to other mosquito-borne flaviviruses such as the dengue, Japanese encephalitis, yellow fever, West Nile viruses. ZIKV causes a disease known as Zika fever, which is characterized by a macropapular rash covering the body, fever, joint pain, and malaise. ZIKV is an important emerging pathogen due to its appearance across the globe, mosquito-driven transmission cycle, and possible spread via sexual contact. Studies have shown that ZIKV can reside in blood transfusions and they can be a possible vector for human-to-human transmission.

Diagnosis for ZIKV infection include PCR tests to detect viral DNA as well as additional tests to detect ZIKV antibody (IgM) in serum. IgM for ZIKV is typically detectable around 3-5 days after infection, but cross-reactivity with closely related dengue, yellow fever, Japanese encephalitis, and West Nile viruses are possible. There is no vaccine for ZIKV or treatment for Zika fever. Symptoms are relatively mild and only supportive therapy is employed.

Zika Virus, Envelope, Recombinant, contains Histidine tag and reacts with both IgG and IgM.

The E protein composes the majority of the virion surface and it is involved with replication, such as host cell binding and membrane fusion.

Recombinant protein corresponding to Zika Virus Envelope, fused to His-tag, expressed in Sf-9 insect cells.

Suitable for use in Lateral Flow. Other applications not tested.

Optimal dilutions to be determined by the researcher.

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Recombinant, Sf9 Insect Cells

≥85% (SDS-PAGE)

~1mg/ml

Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.