CD41, CD61

Grade

Affinity Purified

Purity

Purified by Protein G affinity chromatography from tissue culture supernatant.

Form

Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).

Conjugate

APC

Specificity

Recognizes sheep CD41/CD61. Species Crossreactivity: goat, feline, rabbit, canine, equine and bovine

EU Commodity Code

30021010

Shipping Temp

Blue Ice

Storage Temp

4°C Do Not Freeze

Notes

Preservative Free
BSA Free

CD41/CD61 is also known as GpIIb/IIIa. CD41/CD61 is a calcium-complex dependent heterodimer and is expressed almost exclusively on platelets and on their precursors, the megakaryocytes. This complex is an activation-dependent receptor for RGD (Arg-Gly-Asp)-containing glycoproteins such as fibrinogen, fibronectin, von Willebrand factor, thrombospondin and vitronectin. It plays a central role in platelet aggregation and haemostasis.

Applications

Suitable for use in FLISA, Flow Cytometry and Immunoprecipitation. Other applications have not been tested.

Recommended Dilutions

Optimal dilutions to be determined by the researcher.

Recommended Negative Control

I1904-78R: IgG1 Murine Negative Control

Hybridoma

Sp2-0/AG14 myeloma cells with spleen cells from Balb/c mice.

Storage and Stability

Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Note: Applications are based on unconjugated antibody.

References

1. Brodersen, R. et al. (1998) Analysis of the immunological cross reactivities of 213 well characterized monoclonal antibodies with specificities against various leucocyte surface antigens of human and 11 animal species: Vet. Immunol. Immunopathol. 64: 1-13. 2. Pintado, C. O. et al. (1995) Characterisation of a membrane receptor on ruminants and equine platelets and peripheral blood leucocytes similar to the human integrin receptor glycoprotein IIb/IIIa (CD41/CD61). Vet Immunol. Immunopathol. 44 (3-4): 359-368. 3. Lalko, C. et al. (2003) Equine platelet CD62P (P-selectin) expression: a phenotypic and morphologic study. Vet. Immunol. Immunopathol. 91: 119-134. 4. Major, T.C. et al. (2010) The attenuation of platelet and monocyte activation in a rabbit model of extracorporeal circulation by a nitric oxide releasing polymer. Biomaterials. 31: 2736-45. 5. Brainard, B.M. et al. (2012) Treatment with aspirin or clopidogrel does not affect equine platelet expression of P selectin or platelet-neutrophil aggregates. Vet Immunol Immunopathol. 149: 119-25. 6. Iwaszko-Simonik, A. et al. (2015) Expression of surface platelet receptors (CD62P and CD41/61) in horses with recurrent airway obstruction (RAO). Vet Immunol Immunopathol. 164 (1-2): 87-92.

USBio References

No references available

Product	Ext Price
Subtotal:	Subtotal:
Subtotal:	Subtotal:
Total Coupon Savings:	Total Coupon Savings:	()
Your cart is currently empty.
- Coupon Code

C2394-35A1-APC CD41, CD61 (CD41b, GP2B, GP-IIb, GPIIb, GP3A, GP-IIIa, GPIIIa, GTA, HPA3, Integrin alpha 2b, ITGA2B, Integrin beta 3, ITGB3, Platelet Glycoprotein IIb of IIb/IIIa Complex) (APC)

Grade

Purity

Form

Conjugate

Specificity

EU Commodity Code

Shipping Temp

Storage Temp

Notes

References

USBio References

Pricing

Order

Cart Summary

Recently Viewed

Special Offers

Contact Us

Site Map

Technical Resources

Distributors

Payment Methods