CFL2, Recombinant, Human, aa1-166, His-Tag

Grade

Purified

Purity

≥90% (SDS-PAGE)

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 2mM DTT, 10% glycerol, 50mM sodium chloride.

EU Commodity Code

30021019

Shipping Temp

Blue Ice

Storage Temp

-20°C

CFL2 belongs to the actin-binding proteins ADF family that contains 1 ADF-H domain. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. Defects in CFL2 are the cause of nemaline myopathy type 7 (NEM7).

Source

Recombinant corresponding to aa1-166 from human CFL2, fused to His-tag at N-terminal expressed in E.coli.

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE EAKQILVGDI GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG EKLGGNVVVS LEGKPL

Molecular Weight

~20.9kD (MALDI-TOF)

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Source

Recombinant, E. coli

Purity

≥90% (SDS-PAGE)

Concentration

~1mg/ml

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 2mM DTT, 10% glycerol, 50mM sodium chloride.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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C7506-52 CFL2, Recombinant, Human, aa1-166, His-Tag (Cofilin-2, Cofilin, Muscle Isoform)

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