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041365 S1PR5, ID (S1PR5, EDG8, Sphingosine 1-phosphate receptor 5, Endothelial differentiation G-protein-coupled receptor 8, Sphingosine 1-phosphate receptor Edg-8) CAS:

Specifications
References
Grade
Affinity Purified
Swiss Prot
Q9H228
Specificity
Recognizes human S1PR5.
Gene ID
53637
Gene #
S1PR5
Applications
E WB
Accession Number
NP_001159687.1; NP_110387.1
EU Commodity Code
30021010
Shipping Temp
Blue Ice
Storage Temp
-20°C
S1PR5, EDG8, Sphingosine 1-phosphate receptor 5, Endothelial differentiation G-protein-coupled receptor 8, Sphingosine 1-phosphate receptor Edg-8

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.

Applications
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
References
1. Chang, C.L., et al. Am. J. Physiol., Cell Physiol. 297 (2), C451-C458 (2009) : 2. Gillies, L., et al. Cell. Signal. 21(5):675-684(2009) 3. Miron, V.E., et al. Ann. Neurol. 63(1):61-71(2008) 4. Ulfig, N., et al. Acta Histochem. 106(5):373-378(2004) 5. Vogler, R., et al. J. Invest. Dermatol. 120(4):693-700(2003)
USBio References
No references available
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