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138727 RCAN3, Recombinant, Human, aa56-241, His-Tag (Calcipressin-3, DSCR1L2, hRCN3, MCIP3, RCN3) CAS:

Specifications
References
Grade
Highly Purified
Molecular Weight
23.5
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C

Calcipressin-3, also known as RCAN3, is a 241aa protein that potentially is involved in central nervous system development. RCAN3 inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Overexpression of calcipressin-3 results in inhibition of calcineurin activity towards the nuclear factor of activated T-cells (NFAT) transcription factors and also downregulates NFAT-dependent cytokine gene expression in activated Jurkat T-cells. Highest expression occurs in heart, skeletal muscle kidney, liver and peripheral blood leukocytes.

Source
Recombinant protein corresponding to aa56-241 from human RCAN3 at N-terminal, fused to His-tag expressed in E.coli.
Molecular Weight
~23.5kD (209aa)
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSEAVFEAR EQKERFEALF TIYDDQVTFQ LFKSFRRVRI NFSKPEAAAR ARIELHETDF NGQKLKLYFA QVQMSGEVRD KSYLLPPQPV KQFLISPPAS PPVGWKQSED AMPVINYDLL CAVSKLGPGE KYELHAGTES TPSVVVHVCE SETEEEEETK NPKQKIAQTR RPDPPTAALN EPQTFDCAL
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Purity
~90% (SDS-PAGE)
Concentration
~0.5mg/ml
Form
Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 2M urea, 0.2M sodium chloride, 20% glycerol.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Strippoli P., et al. (2000) Genomics. 64:252-263. 2. Abbasi S., et al. (2006) J Biol Chem. 281:7717-7726.
USBio References
No references available
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