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218401 NRF2, Recombinant, Human, aa1-605, His-Tag (Nuclear Factor (Erythroid-Derived 2)-Like 2, NFE2L2) CAS:

Specifications
References
Grade
Purified
Accession Number
NP_037533
Molecular Weight
69.9
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C

Nuclear factor (erythroid-derived 2)-like 2, also known as NRF2, is a bZIP transcription factor that heterodimerize with Maf proteins to bind Mare sequences. The NRF proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. NRF2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from its repressor protein, Keap1.

Source
Recombinant protein corresponding to aa1-605 from human NRF2, fused to His-tag at N-terminus, expressed in E.coli.
Molecular Weight
~69.9kD (625aa)
Applications
Suitable for use in SDS-PAGE. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Purity
~85% (SDS-PAGE)
Concentration
~0.1mg/ml
Form
Supplied as a liquid in PBS, pH 7.4, 10% glycerol.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Huang H C., et al. (2000) Proc Natl Acad Sci uSA. 97: 12475-12480. 2. Tsai P Y., et al. (2012) Arthritis Rheum. 64: 232-242.
USBio References
No references available
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