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351545 TSC22D3, Recombinant, Human, aa1-134, His-Tag |(TSC22 Domain family protein 3, DIP, DSIPI, GILZ, hDIP, TSC-22R) CAS:

Specifications
References
Grade
Purified
Accession Number
NP_004080
Molecular Weight
17.2
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C

TSC22 domain family protein 3, also known as TSC22D3, protects T-cells from IL2 deprivation- induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, TSC22D3 plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, TSC22D3 inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities.

Recombinant protein corresponding to aa1-134 from human TSC22D3, fused to His-tag at N-terminal expressed in E. coli.
Molecular Weight
~17.2kD(157aa)
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMNTEMYQ TPMEVAVYQL HNFSISFFSS LLGGDVVSVK LDNSASGASV VAIDNKIEQA MDLVKNHLMY AVREEVEILK EQIRELVEKN SQLERENTLL KTLASPEQLE KFQSCLSPEE PAPESPQVPE APGGSAV
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Purity
≥85% (SDS-PAGE)
Concentration
~1mg/ml
Form
Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 0.15M sodium chloride, 1mM DTT, 10% glycerol.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Asselin-Labat M.-L., et al. (2004) Blood. 104:215-223 2.Berrebi D., et al. (2003) Blood. 101:729-738
USBio References
No references available
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