C-Reactive Protein, Recombinant, Human CAS 99401-15-7

CAS Number

99401-15-7

Grade

Highly Purified

Molecular Weight

23.047

EU Commodity Code

30021019

Shipping Temp

Blue Ice

Storage Temp

4°C Do Not Freeze

CRP is an acute phase protein that correlates with inflammatory disease and is synthesized by hepatocytes during the acute phase response by certain cytokines (IL-1 and TNF Alpha and Beta). CRP levels increase dramatically (up to 1,000 fold) and serve as a useful marker of inflammation in such conditions as bacterial infection, rheumatoid arthritis, viral infections, transplantation rejection, meningitis, myocardial infarction, septicemia, osteomyelitis and others. CRP is also highly correlated to Serum Amyloid A levels.

Recombinant CRP is a pentamerized active molecule secreted into culture medium during E.coli fermentation with host cells having human CRP gene, allowing r-hCRP to be excreted without cell lysis. The patented technology specifies only active r-hCRP to be manufactured, which is equivalent to native one originated from human tissues. The recombinant CRP is affinity-purified by use of phosphorylcholine conjugated matrices. As a result, the final product presents the longest stability for 2 years as supplied refrigerated.

Recombinant CRP monomer is made of 206 amino acids, and has the same amino acid sequence as native human CRP.

Applications

Standard antigen for CRP determination, rhCRP has been evaluated as a secondary reference material to meet standardization of high sensitive CRP assay. High qualified antigen for antibody production.

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Source

Recombinant, E. coli

Purity

Purified by immunoaffinity chromatography. ≥ 96% by SDS-PAGE

Concentration

~1mg/ml

Form

Supplied as a liquid in TBS, pH 7.5, 2mM CaCl2, 0.05% sodium azide.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. C-reactive protein: crystal ball or redundancy? Is this heart risk biomarker useful independently, or does it only confirm the results of other tests? Health News 10(12): 3 (2004, Dec). 2. Nissen, S.E., Tuzcu, E.M., Crowe, T., Magorien, R.D.: Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N. Engl. J. Med. 352(1): 29-38 (2005, Jan 6). 3. Ridker, P.M., Cannon, C.P., Rifai, N., Braunwald, E.: C-reactive protein levels and outcomes after statin therapy. N. Engl. J. Med. 352(1): 20-8 (2005, Jan 6). 4. Hammett, C.J., Oxenham, H.C., Doughty, R.N., Stewart, R.A.: Effect of six months' exercise training on C-reactive protein levels in healthy elderly subjects. J. Am. Coll. Cardiol. 44(12): 2411-3 (2004, Dec 21). 5. Niizuma, T., Terada, K., Daimon, Y., Tanaka, K.: Elevated serum C-reactive protein in mumps orchitis. Pediatr. Infect. Dis. J. 23(10): 971 (2004, Oct). 6. Casamassima, A., Picciariello, M., Berardino, R., Guida, M.: C-reactive protein: a biomarker of survival in patients with metastatic renal cell carcinoma treated with subcutaneous interleukin-2 based immunotherapy. J. Urol. 173(1): 52-5 (2005, Jan).

USBio References

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C7907-28B C-Reactive Protein, Recombinant, Human (CRP, MGC88244, PTX 1, PTX1) CAS: 99401-15-7

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