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F0019-61MX Fas IgG1 Fc & Hinge Region, Fusion Protein (CD95, APO-1) (Preservative Free) CAS:

Specifications
References
Grade
Affinity Purified
Applications
E
Molecular Weight
44.3
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze
Preservative Free
Yes
Notes
Preservative Free

Human CD95 (APO-1/FAS) is a type I cell surface glycoprotein that is strongly upregulated on activated T cells, B cells, NK cells and thymocytes (1). CD95 plays an important role in programmed cell death or apoptosis (2). Apoptosis appears to be a mechanism for regulating the immune response (3, 4).

Molecular Structure: A soluble fusion protein consisting of the mature extracellular (150 aa) domain of human CD95 fused to a linker (7 aa) and human IgG1 Fc + hinge (229 aa), with a predicted monomeric molecular weight of 44.3kD.
Transfectant Cell Line: CHO
Functional Application: CD95-huIg fusion protein inhibits CD95 ligand mediated apoptosis of Jurkat cells.
Applications
Suitable for use in ELISA. Other applications not tested.
Recommended Dilution Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Source
CHO cells
Purity
Purified by affinity chromatography.
Concentration
~0.5mg/ml
Form
Supplied as a liquid in FBS, 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl. No preservative added.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
(1). Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford (1995) p. 1142-1148. |(2). S. Nagata & P. Golstein (1995) Science 267: 1449-1456. |(3). S. Nagata & T. Suda (1995) Immunol Today 16: 39-43. |(4). D.H. Lynch, F. Ramsdell & M.R. Alderson (1995) Immunol Today 16: 569-574.
USBio References
No references available
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