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F6069-95H Fractalkine, Recombinant, Human (Neurotactin, CX3CL1, FKN) CAS:

Specifications
Grade
Highly Purified
Swiss Prot
P78423
Gene ID
6376
Molecular Weight
8.5
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C
Preservative Free
Yes
Notes
Preservative Free

Fractalkine is a CX3CL chemokine that signals through the CX3CR1 receptor. Fractalkine has been shown to chemoattract monocytes, microglia cells and NK cells. Fractalkine is, at this time, the only CXC3C chemokine that contains three amino acid residues between the first and second cysteine residues of the chemokine domain. The Fractalkine gene encodes for a 397 amino acid precursor protein containing a 24 amino acid signal sequence, a chemokine domain, and a "mucin-like stalk" sequence, which is followed by the transmembrane domain containing approximately 20 amino acids, and a C-terminal cytoplasmic domain. The extracellular chemokine domain contains 76 amino acid residues, including the four conserved cysteine residues found in other chemokines. Recombinant Human Fractalkine is an 8.5kD protein containing 76 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Recombinant protein corresponding to human Fractalkine, expressed in E.coli.
Amino Acid Sequence
QHHGVTKCNI TCSKMTSKIP VALLIHYQQN QASCGKRAII LETRQHRLFC ADPKEQWVKD AMQHLDRQAA ALTRNG
Biological Activity
Determined by its ability to chemoattract human T cells using a concentration range of 5-10 ng/ml.
Storage and Stability
Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile PBS, 0.1% BSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Form
Supplied as a lyophilized powder in PBS. Reconstitute with sterile PBS containing 0.1% BSA to 0.1-1mg/ml.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
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