Immunoglobulin G (IgG) are antibody molecules. Each IgG is composed of four peptide chains-two heavy chains and two light chains. Each IgG has two antigen binding sites. Other Immunoglobulins may be described in terms of polymers with the IgG structure considered the monomer. IgG constitutes 75% of serum immunoglobulins in humans. IgG molecules are synthesized and secreted by plasma B cells. There are 4 IgG isotypes, IgG1, IgG2, IgG3 and IgG4. IgG2 makes up 23% of total IgG.
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