RANTES is a protein which has been shown to be a chemo-attractant for peripheral blood monocytes. It appears to selectively attract T cells of the CD4+/CD45RO+ phenotype in vitro. Rat RANTES is a 7.9kD protein containing 68 amino acid residues.
Biological Activity
Rat Rantes produces chemotaxis over a wide concentration range in assay using rat peritoneal macrophages. Significant chemotaxis was achieved using a concentration of 50-100ng/ml.
Responding Cells (partial list)
Monocytes, T cells, others
Amino Acid Sequence
SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS
Storage and Stability
Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Source
Recombinant, E. coli
Form
Supplied as a lyophilized powder with no additives. Reconstitute with sterile ddH2O to a concentration of 0.1-1.0mg/ml. Do not vortex. For long term add protein carrier. It is recommended that further dilutions be made into other aqueous buffers.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
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