Streptolysin O, isolated from human plasma. Streptolysin-O (SLO) is a bacterial protein that forms an alpha helix and is toxic to eukaryotic cells. Its toxic effect is due to the protein's ability to bind to cholesterol and form holes in the plasma membrane of cells. This ability can be utilized in the laboratory to create holes in the plasma membrane but not other membranes.
Streptolysin is a hemolysin produced by group A streptococci. In an infected individual streptolysin O acts as a protein antigen, and the patient mounts an antibody response. A rise in anti-streptolysin O level begins about 1 week after infection and peaks 2-3 weeks later. In the absence of complications or reinfection, the anti-streptolysin O ASO titer will usually fall to preinfection levels within 6-12 months. Both clinical and laboratory findings should be correlated in reaching a diagnosis.
Streptococcal infections are caused by bacteria known as Streptococcus. There are several disease-causing strains of streptococci (groups A, B, C, D, and G), which are identified by their behavior, chemistry, and appearance. Each group causes specific types of infections and symptoms. These antibody tests are useful for group A streptococci. Group A streptococci are the most virulent species for humans and are the cause of strep throat, tonsillitis, wound and skin infections, blood infections (septicemia), scarlet fever, pneumonia, rheumatic fever, Sydenham's chorea (formerly called St. Vitus' dance), and glomerulonephritis.
Supplied as a concentrate for research and diagnostic manufacturing.
Activity
≥500 IU/mL (Beckman Array)
Storage and Stability
May be stored at 4°C. Do not freeze. Stable for 6 months after receipt.
Form
Supplied as a sterile-filtered liquid, pH 7.1, 0.09% sodium azide.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
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