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Z0550-01A ZIPK, Control Peptide (ZIPtide, Zip Kinase) CAS:

Specifications
References
Grade
Highly Purified
Molecular Weight
1460.69
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Synthetic substrate peptide (KKLNRTLSFAEP-G) (linear) for ZIPK.

Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase. ZIP kinase contains an N-terminal kinase domain and a C-terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREB family. ZIP kinase has high sequence homology to DAP kinase (death-associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities.
Applications
Analytical Tests: Peptide identity confirmed by MALDI-ToF MS and Amino Acid analysis. Kinase Assay: Substrate for ZIPK, active.
Storage and Stability
Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Synthetic peptide
Purity
95+%, HPLC, Mass Spec
Form
Supplied as a lyophilized powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Kawai, T, et al., Mol. Cell Biol, 18: 1642-1651, 1998.
USBio References
No references available
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