DNA methyltransferase 1-associated protein (DMAP1) is found in a wide variety of living organisms from yeasts to humans. MMTR is a part of the basic cellular machinery for a wide range of transcriptional regulation via interaction with TFIIH and HDAC. DMAP1 is incorporated by Bmi1 in polycomb gene silencing. The DMAP1 gene works as a mutagen for tumor suppressor genes by causing hypermethylation and subsequent TA mutations of CpG islands. The direct role of Dnmt1 is restoration of epigenetic information during DNA repair. In eukaryotes the NuA4 histone acetyltransferase (HAT) complex is highly conserved and plays primary role in transcription, cellular response to DNA damage and cell cycle control.