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A0859-35B Rabbit Anti-ADAM 17, CT (A Disintegrin And Metalloproteinase 17, TNF-a Converting Enzyme, TACE, TNF alpha Converting Enzyme, CD156b)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P78536
Isotype
IgG
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu Ma
Shipping Temp
Blue Ice
Storage Temp
-20°C

ADAM-17, which is also known as CD156b, is expressed in a wide range of cells in culture. Its biological role is to convert the transmembrane trimeric form of TNF alpha to the soluble form. CD156 is also reported to process a number of other proteins, including L-selectin and TNF p75 receptor.

Applications
Suitable for use in Western Blot. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:500 Optimal dilutions to be determined by researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Peptide corresponding to aa807-823 of human CD156b
Form
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity
Purified by affinity chromatography from whole serum.
Specificity
Recognizes the C-terminal region of the TNF alpha converting enzyme (TACE), designated CD156b at the 6th leukocyte typing workshop. TACE is a membrane-bound metalloprotease disintegrin which belongs to the mammalian ADAM family.
References
1. Moss, M. L. et al. (1997). Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor - alpha. Nature. 385: 733-736
USBio References
No references available
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