Mrc2 (C-type Mannose Receptor 2; also MMR2, Endocytic Receptor 180 and uPARAP) is a 180-200kD member of the macrophage mannose receptor family of proteins. It is widely expressed, being found on fibroblasts, monocytes/macrophages, endothelial cells, keratinocytes and myoepithelial cells. It binds the carbohydrates Man, Fuc and NAcGlc, type V collagen, and pro-uPA. Mature human Mrc2 is a 1449aa type I transmembrane protein. It contains a 1384aa extracellular region and a 44aa cytoplasmic domain. The extracellular region shows one ricin B-type lectin domain (aa41-167), one fibronectin type II domain (aa182-230) and eight C-type lectin domains (aa244-1393). Over aa 800-1059, human Mrc2 shares 87% aa identity with mouse Mrc2.
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