Superoxide Dismutase 1 (SwissProt P00441) is a major antioxidant enzyme that catalyzes the conversion of superoxide anion to hydrogen peroxide and molecular oxygen. SOD1 is ubiquitously expressed and is localized in the cytosol, nucleus, and mitochondrial intermembrane space. Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1).
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