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006833 Ciliobrevin A CAS: 302803-72-1

Specifications
References
CAS Number
302803-72-1
Grade
Highly Purified
Molecular Formula
C17H9Cl2N3O2
Molecular Weight
358.18
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
RT
2,4-Dichloro-α-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile; HPI-4; |

Ciliobrevin A is a Hedgehog pathway inhibitor; ciliogenesis inhibitor. The Hedgehog (HH) signaling pathway is targeted for anti-cancer therapeutics. Ciliobrevin A inhibited proliferation of cerebellar granula neuron precursor cells, an important model of HH signaling.

References
Heald, R., et al.: Nature, 382, 420 (1996), Gaglio, T., et al.: J. Cell Biol., 138, 1055 (1997), Zhu, G., et al.: J. Med. Chem., 49, 2063 (2006), Varma, D., et al.: J. Cell Biol., 182, 1045 (2008),
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