PD 173074 CAS 219580-11-7

CAS Number

219580-11-7

Grade

Highly Purified

MDL Number

MFCD08705327

Molecular Formula

C28H41N7O3

Molecular Weight

523.7

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

Synonyms

PD173074, UNII-A4TLL8634Y, FGF/VEGF Receptor Tyrosine Kinase Inhibitor

Chemical Name

1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrim idin-7-yl]urea

Molecular Formula

C28 H41 N7O3

Molecular Weight

523.7

CAS Number

219580-11-7

Purity

≥98%

Applications

Appearance

Crystalline solid

Description

PD 173074 is a potent and selective inhibitor of fibroblast growth factors, FGFR1 and FGFR3. It is reported to suppress the differentiation of mouse embryonic cells and promote the survival of human embryonic cells. PD 173074 potently and selectively antagonizes the neurotrophic and neurotropic actions of FGF-2 and displays anti-cancer properties.

Storage

Soluble in DMSO up to 20 mM.

Purity

Highly Purified (~98%)

Concentration

Not determined

Form

Supplied as a crystalline solid.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Skaper, S. D., Kee, W. J., Facci, L., Macdonald, G., Doherty, P., & Walsh, F. S. (2000). The FGFR1 Inhibitor PD 173074 Selectively and Potently Antagonizes FGF‐2 Neurotrophic and Neurotropic Effects. Journal of neurochemistry, 75(4), 1520-1527. 2. Mohammadi, M., Froum, S., Hamby, J. M., Schroeder, M. C., Panek, R. L., Lu, G. H., ... Hubbard, S. R. (1998). Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. The EMBO journal, 17(20), 5896-5904. 3. Dimitroff, C. J., Klohs, W., Sharma, A., Pera, P., Driscoll, D., Veith, J., Bernacki, R. J. (1999). Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy. Investigational new drugs,17(2), 121-135.

USBio References

No references available

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366905 PD 173074 (PD173074, UNII-A4TLL8634Y, FGF/VEGF Receptor Tyrosine Kinase Inhibitor) CAS: 219580-11-7

CAS Number

Grade

MDL Number

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

References

USBio References

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