Insulin-Like Growth Factor I CAS

Brand

MaxLight™

Grade

Affinity Purified

EU Commodity Code

30021010

Shipping Temp

Blue Ice

Storage Temp

4°C Do Not Freeze

Notes

Preservative Free
BSA Free

Insulin-like Growth Factor IA, IGF-IA, IGF1A, Insulin-like Growth Factor IB, IGF-IB, IGF1B

MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000.

Growth Factor I, a 70aa secreted mitogenic polypeptide and member of the insulin gene family, produced primarily by the liver. IGFI exhibits both autocrine and paracrine properties and has a widespread effect on cells including those of the bone, cartilage, muscle, nerves, skin, liver and lungs, playing a key role in cell proliferation and growth, inhibition of apoptosis and linked with tumor cell growth.

IGFI signals through binding to the type 1 insulinlike growth factor receptor (IGF1R) and also to the insulin receptor (IR), resulting in the activation of the AKT signalling pathway. Production of IGFI is stimulated by growth hormone (GH) and can be hindered by GH insensitivity, deficiency in GH receptors or a malfunction in the post GH receptor signalling pathway.

Applications

Suitable for use in FLISA, Functional Assays, and Western Blot. Other applications not tested.

Recommended Dilution

FLISA: 0.5-2ug/ml Western Blot: 0.1-0.2ug/ml Functional Assays: 0.67-1ug/ml Optimal dilutions to be determined by the researcher.

Storage and Stability

Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Note: Applications are based on unconjugated antibody.

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I7661-02B-ML650 Insulin-Like Growth Factor I (IGF1, IGF I, IGF-I, IBP1, Mechano Growth Factor, MGF, Somatomedia C, Somatomedin C) (MaxLight 650) CAS:

Brand

Grade

EU Commodity Code

Shipping Temp

Storage Temp

Notes

Insulin-like Growth Factor IA, IGF-IA, IGF1A, Insulin-like Growth Factor IB, IGF-IB, IGF1B

References

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