Rimacalib, a inhibitor of CaMKII, inhibits VEGF expression in human acute monocytic leukemia cell and SF macrophage obtained from patient with rheumatoid arthritis. This effect may contribute to the anti-arthritic effects of Rimacalib. The IC50s of Rimacalib are ~1uM for CaMKIIα to ~30uM for CaMKIIγ.
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