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464725 Rimacalib

Specifications
References
Purity
≥99%
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
SMP 114; N-[3-[(1S)-1-(2-Fluoro[1,1'-biphenyl]-4-yl)ethyl]-5-isoxazolyl]-4-morpholinecarboximidamide

Rimacalib, a inhibitor of CaMKII, inhibits VEGF expression in human acute monocytic leukemia cell and SF macrophage obtained from patient with rheumatoid arthritis. This effect may contribute to the anti-arthritic effects of Rimacalib. The IC50s of Rimacalib are ~1uM for CaMKIIα to ~30uM for CaMKIIγ.

Synonyms
SMP 114; N-[3-[(1S)-1-(2-Fluoro[1,1'-biphenyl]-4-yl)ethyl]-5-isoxazolyl]-4-morpholinecarboximidamide
CAS No
215174-50-8 HCl Salt: 215174-78-0
Molecular Formula
C₂₂H₂₃FN₄O₂
Molecular Weight
394.44
Appearance
Supplied as a off-white to pale orange solid
Purity
≥99%
Melting Point
>56°C (dec.)
Solubility
Chloroform (Slightly), Methanol (Slightly), DMSO (125mg/ml)
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Westra, Johanna., et al.: BMC Musculoskelet Disord.,11 ,  No pp. given. (2010)|2. Neef S, et al. Reduction of SR Ca2+ leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability. Basic Res Cardiol. 2017 Jul;112(4):45.
USBio References
No references available
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