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037172 JAG1, CT (JAG1, JAGL1, Protein jagged-1, CD339)

Specifications
References
Grade
Affinity Purified
Purity
Purified by Protein A and peptide affinity chromatography
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide
Specificity
Recognizes human JAG1
EU Commodity Code
30021010
Shipping Temp
Blue Ice
Storage Temp
-20°C
JAG1, JAGL1, Protein jagged-1, CD339

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

Applications
Suitable for use in Western Blot, Indirect Flow Cytometry and ELISA. Other applications not tested.
Recommended Dilutions
Western Blot: 1:1000 Flow Cytometry (Indirect): 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
References
1. Foldi, J., et al. J. Immunol. 185(9):5023-5031 (2010). 2. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253 (2010). 3. Kerns, D., et al. Schizophr. Res. 120 (1-3), 150-158 (2010). 4. Siar, C.H., et al. Eur. J. Med. Res. 15(4):180-184 (2010). 5. Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010)
USBio References
No references available
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