Cdc14, also known as duel specificity phosphatase, is a protein phosphatase originally discovered in yeast that plays an important role in cell cycle regulation, including exit from mitosis. Throughout G1, S and G2 phases, Cdc14 is located in the nucleolus; at the beginning of anaphase, the protein is redistributed throughout the entire nucleus. In late anaphase, Cdc14 dephosphorylates Cdh1 which then activates APC (Anaphase Promoting Complex). Two human orthologs of yeast Cdc14 have been identified; these are Cdc14A and Cdc14B, and they share about 80% amino acid homology in the N-termini and phosphatase domains. Cdc14 has also been shown to dephosphorylate p53, suggesting that it may play a role in regulation of p53 activity.