Go6976|12- CAS 136194-77-9

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G8569-01 Go6976|12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-|5-oxo-5H-indolo[2,3-a]pyrrollo[3,4-c]carbazole CAS: 136194-77-9

Specifications

References

CAS Number

136194-77-9

Grade

Highly Purified

Molecular Formula

C24H18N4O

Molecular Weight

378.43

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Novel, very potent PKC inhibitor with high selectivity for the A-group of PKC isotypes (a, b and gamma), with IC50 values in the 2-10nM range. Little or no inhibition of the B- and C-groups of PKC isotypes, even at much higher concentrations.

Solubility

Soluble in DMSO.

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Purity

~99%

Form

Supplied as an off-white to yellow powder.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Kleinschroth, J., Hartenstein, J., Rudolph, C. and Schächtele, C. "Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C." Bioorg. Med. Chem. Lett. 3:1959-1964 (1993). Martiny-Baron, G., Kazanietz, M.G., Mischak, H., Blumberg, P., Kochs, G., Hug, H., Marme, D. and Schächtele, C. "Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976." J. Biol. Chem. 268:9194-9197 (1993).